ArticleJournal of orthopaedic surgery and research2026
miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A.
Article in Journal of orthopaedic surgery and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aims to investigate the expression characteristics, clinical diagnostic value of miR-1290 in osteoporotic fracture (OPF) patients, and its regulatory mechanism in osteoblast function.
methods289 subjects were divided into healthy control, OP, and OPF groups. Serum miR-1290 levels were detected by RT-qPCR, and its diagnostic efficacy was evaluated via ROC curve analysis. Functional experiments were conducted using hFOB1.19 cells to explore miR-1290's expression pattern during osteogenic differentiation and its effects on cell proliferation and differentiation. Bioinformatics prediction, dual-luciferase reporter assay, and RIP assay were used to verify the target gene of miR-1290.
resultsSerum miR-1290 levels showed a gradient decrease from healthy controls to OP and OPF patients. It had favorable diagnostic efficacy for distinguishing OPF from OP patients. OPF patients' postoperative miR-1290 levels gradually increased. miR-1290 was upregulated during osteogenic differentiation and promoted osteoblast proliferation and differentiation. KDM5A was identified as a direct target of miR-1290, and their expressions were negatively correlated. KDM5A overexpression reversed miR-1290's enhancement of osteoblast proliferation and differentiation.
conclusionmiR-1290 is downregulated in OP and OPF patients and promotes osteoblast function by targeting KDM5A, which highlights the role of the miR-1290/KDM5A axis in OPF and offers new insights for clinical diagnosis and targeted therapy.
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