ArticleBMC oral health2026
Ligature-induced periodontitis exacerbates high-carbohydrate/high-fat diet-induced fatty liver in mice under non-diabetic conditions.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRecent studies have suggested that periodontitis affects non-alcoholic fatty liver disease (NAFLD). Until now, the underlying mechanisms have mainly been investigated in the context of diabetes, which is a risk factor for NAFLD. However, clinical research indicates that 80% of NAFLD patients do not have diabetes, with a complication rate of 40% even in advanced cases. In this study, we investigated whether periodontitis exacerbates NAFLD under non-diabetic conditions using a high-carbohydrate/high-fat diet (HCHFD).
methodsWe first developed non-diabetic NAFLD mice induced by an HCHFD and then analyzed the effect of ligature-induced periodontitis in an established NAFLD mouse model. Mice were fed a normal chow (NC), an HCHFD, or a high-fat diet (HFD), a commonly used diet in previous NAFLD studies for 6 weeks.
resultsHCHFD induced hepatic steatosis without causing glucose intolerance or insulin resistance, whereas a HFD showed glucose intolerance accompanied by hepatic steatosis. Ligature-induced periodontitis facilitated HCD-induced steatosis and caused interlobular fibrosis in the liver.
conclusionA non-diabetic mouse model for NAFLD, closer to the clinical presentation than pre-existing mouse models, indicated that ligature-induced periodontitis exacerbated non-diabetic NAFLD, which accounts for the majority of the NAFLD population.
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