ReviewJournal of translational medicine2026
The role of histone methylation in fibrosis and its therapeutic potential.
Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the role of epigenetics in the processes related to the development of endometrosis in the mare.The Journal of reproduction and development · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundFibrosis is a pathological process characterized by excessive extracellular matrix deposition, leading to tissue stiffening and organ dysfunction, posing a significant threat to human health. In recent years, histone methylation, a key epigenetic modification, has been increasingly recognized for its crucial regulatory role in the initiation and progression of fibrosis. By modulating chromatin structure and gene expression, histone methylation influences the activation of fibrosis-related cells, inflammatory responses, and cellular fate transitions. MAIN BODY: This review systematically summarizes the molecular mechanisms of histone methylation in fibrosis across multiple organs, including the kidney, liver, heart, and lungs. It emphasizes the functions and regulatory networks of methyltransferases and demethylases, integrating the latest experimental and clinical findings. Furthermore, potential therapeutic strategies targeting histone methylation are discussed, highlighting their promise for precise anti-fibrotic interventions.
conclusionsBy consolidating advances in multi-organ fibrosis research, this article aims to provide a theoretical foundation and practical guidance for the future development of targeted fibrosis therapies.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.