Evidence map›Paper›PMID 41782859›Full record

ArticleFrontiers in immunology2026

Application of a small molecule calcium influx inducer as a vaccine adjuvant: enhancing Th2-biased immune responses.

Yumi Yokoyama, Yukiya Sako, Shiyin Yao, Fernando Gil, Renna Cozza, Jasmine Jin, Ian Mclaughlin, Paola Anguiano Quiroz, Tyler Brown, Nikunj M Shukla and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yumi YokoyamaDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Yukiya SakoDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Shiyin YaoDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Fernando GilDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Renna CozzaDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Jasmine JinDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Ian MclaughlinDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Paola Anguiano QuirozDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Tyler BrownDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Nikunj M ShuklaDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Michael ChanDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Maripat CorrDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Dennis A CarsonDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Tomoko HayashiDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Vaccines are highly effective in preventing the spread of communicable diseases and are critical to overall public health. As immune stimulants vaccine adjuvants augment the level and longevity of these protective responses. Seeking novel adjuvants using parallel high throughput screens and subsequent systematic structure-activity relationship studies we identified an analogue of a hit compound, Methods: Results: Discussion:

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineCalciumTh2 CellsAnimalsCytokinesDendritic CellsFemaleImmunoglobulin GLymphocyte ActivationMiceMice, Inbred BALB CAdjuvants, ImmunologicAdjuvants, VaccineCalciumCytokinesImmunoglobulin GadjuvantCa2+ influxdendritic cellextracellular vesicleT helper 2vaccine

Identifiers

PMID41782859
PMCPMC12953538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.