ArticleAdvances in radiation oncology2026
Kupffer Cell-Derived Interleukin-6 Aggravates Radiation-Induced Liver Disease by Activating Hepatocyte STAT3 to Promote
Article in Advances in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
9 authors.
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Abstract
Background: Radiation-induced liver disease (RILD) is a serious complication of radiation therapy for upper abdominal tumors, the cellular and molecular basis of which remain mostly unclear. Methods and Materials: Single-cell RNA sequencing (scRNA-seq) analysis of rat liver tissues was conducted to identify the key cytokines regulating RILD. Critical downstream target genes of RILD were determined using a chromatin immunoprecipitation (ChIP) assay. The BRL-3A cell line was selected for in vitro experiments. Results: Pathological damage and immune cell infiltration were most severe at 2 weeks after irradiation (IR). ScRNA-seq analysis revealed that Kupffer cells represented the highest proportion of cells after IR (42.4%) and characteristically expressed Conclusions: Paracrine secretion of IL-6 by Kuppfer cells activates STAT3 in hepatocytes through classical signaling. Activated STAT3 increases
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Registered trials
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