ArticleFrontiers in oncology2026
Pre-treatment peripheral absolute monocyte count predicts metastatic progression and survival outcomes in treatment-naive non-metastatic nasopharyngeal carcinoma.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The tumor node metastasis (TNM) staging system does not fully capture tumor heterogeneity, underscoring the needs for reliable biomarkers for prognostication in non-metastatic nasopharyngeal carcinoma (NPC). While inflammatory markers have shown potential, the prognostic value of pre-treatment peripheral absolute monocyte count (AMC) in treatment-naive, non-metastatic NPC remains underexplored. Methods: This retrospective cohort study analyzed 2,046 patients with newly diagnosed treatment-naive, non-metastatic NPC from 2009 to 2022. The optimal AMC cut-off value (0.63×10 Results: Over a median follow-up of 77.4 months, distant metastasis, bone metastasis, and death occurred in 13.5%, 6.9%, and 24.2% of patients, respectively. High pre-treatment AMC was independently associated with significantly worse DMFS (hazard ratio [HR]=1.33, 95% confidence interval [CI]: 1.05-1.70, P = 0.020), BMFS (HR = 1.86, 95%CI: 1.33-2.60, P<0.001), and OS (HR = 1.34, 95%CI: 1.11-1.61, P = 0.002) in fully adjusted models. RCS revealed a linear association between AMC and metastasis risk (P for non-linearity >0.05), but a non-linear threshold effect for OS (P for non-linearity=0.011). The risk of all-cause mortality increased with AMC >0.54×10 Conclusion: Pre-treatment peripheral AMC ≥0.63×10
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