Evidence map›Paper›PMID 41783488›Full record

ArticleACS applied nano materials2026

Cytosolic Delivery of a Bithiophene Derivative via Polymersomes Kills

Rayanne Regina Beltrame Machado, Débora B Scariot, Amanda Beatriz Kawano Bakoshi, El Hadji Arona Mbaye, Sultan Almunif, Swagat Sharma, Deysiane Lima Salvador, Caroline Fortuna, Sueli de Oliveira Silva Lautenschlager, Tânia Ueda Nakamura and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cell Death and Unprecedent Cytoskeletal Changes inChemical & biomedical imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rayanne Regina Beltrame MachadoLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Débora B ScariotDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0002-8681-0172
Amanda Beatriz Kawano BakoshiLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
El Hadji Arona MbayeDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0009-0000-7223-6977
Sultan AlmunifDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0002-9514-5549
Swagat SharmaDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
Deysiane Lima SalvadorPrograma de Pós-graduação em Química, Departamento de Química, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Caroline FortunaPrograma de Pós-graduação em Química, Departamento de Química, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Sueli de Oliveira Silva LautenschlagerLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Tânia Ueda NakamuraLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Maria Helena SarragiottoPrograma de Pós-graduação em Química, Departamento de Química, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.ORCID https://orcid.org/0000-0003-3861-502X
Danielle Lazarin BidóiaLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.
Evan ScottDepartment of Biomedical Engineering, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois 60208, United States.
Celso Vataru NakamuraLaboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básica da Saúde, Universidade Estadual de Maringá (UEM), Maringá, Paraná 87020-900, Brasil.ORCID https://orcid.org/0000-0002-9911-7369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease, caused by the protozoan

Indexed as

amastigotesbithiophene derivativeChagas diseasedrug deliveryimmunomodulationpolymersomes

Identifiers

PMID41783488
PMCPMC12954673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.