ArticleMarine life science & technology2026
Glycogenic hepatopathy in a primitive teleost fish model: the inductive effect of high carbohydrate diet and the alleviating role of betaine.
Article in Marine life science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Dietary carbohydrate-to-lipid ratios influences muscle composition, metabolism, and liver histology in Tropical Gar (Atractosteus tropicus).Tropical animal health and production · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate-induced glycogenic hepatopathy is underdiagnosed and difficult to discriminate from hepatic steatosis in humans. The present study used liver biopsy and other diagnostic tools, and adopted metabolomic technology to identify glycogenic hepatopathy rather than hepatic steatosis in largemouth bass induced by high carbohydrate diet (HC). HC induced obvious liver injury in largemouth bass with disarranged hepatocytes, partial cell membrane damage, and irregular distribution of nuclei, accompanied by increased serum ALT and AST activities. PAS staining and glycogen content analysis detected significant increases in liver glycogen content, whereas intrahepatic triglyceride content and programmed cell death were not affected. Metabolomic analysis indicated that up-regulated metabolites were mainly enriched in glycogen synthesis precursors, whereas betaine and unsaturated fatty acids were down-regulated, confirming that HC induced glycogenic hepatopathy rather than hepatic steatosis in largemouth bass. The significantly decreased betaine in both serum and liver of largemouth bass served as a potential key regulator in such disease, whose supplementation could alleviate HC-induced liver injury and serum ALT activity. Betaine supplementation increased betaine and carnitine contents in liver and serum, resulting in decreased hepatic glycogen deposition and cortisol content in largemouth bass. Further study showed that dietary betaine significantly improved the capacity of largemouth bass to resist against ammonia stress. Therefore, our study established a glycogenic hepatopathy-inducing and evaluation model in a primitive teleost and also identified the betaine as the key metabolic marker and prevent strategy, which help advance the understanding of human liver diseases. Supplementary Information: The online version contains supplementary material available at 10.1007/s42995-025-00301-0.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.