ArticleDrug design, development and therapy2026
GLUT5-Driven Gut-Liver Axis Injury Mediating Olanzapine-Induced NAFLD and Dapagliflozin Intervention.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: Drugs are an important cause of non-alcoholic fatty liver disease (NAFLD), and olanzapine is the main drug that leads to NAFLD. However, the mechanism by which this drug causes NAFLD is still unclear at present. We previously found that dapagliflozin had certain intervention effect on patients with NAFLD. This study aimed to explore the mechanism of olanzapine-induced NAFLD and the intervention effect of dapagliflozin. Methods: Twenty-four female wistar rats were classified into control (NC) group, olanzapine (OLA) group, and dapagliflozin intervention (DAP) group for a total of 12 weeks of intervention. This study explored the specific mechanism of olanzapine-induced NAFLD and potential treatment method from dapagliflozin through transcriptomics, molecular biology, and pathological staining methods in animal models. Results: The transcriptome and immunohistochemistry studies of the intestine and liver revealed the high expression of GLUT5 in both tissues ( Conclusion: The study discovered for the first time that GLUT5/AMPK/mTOR drived gut-liver axis injury mediating olanzapine-induced NAFLD and dapagliflozin intervention could reverse GLUT5/AMPK/mTOR-driven gut-liver axis injury ameliorating olanzapine-induced NAFLD. This provided a new understanding of the occurrence of olanzapine-induced NAFLD and offered a reference plan for its clinical intervention.
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