ReviewJNMA; journal of the Nepal Medical Association2025
Conundrum of Cholesterol Management and Health Implications of Low Cholesterol Levels: A Narrative Review.
Review in JNMA; journal of the Nepal Medical Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lowering cholesterol for the health benefit of dyslipidemia is a well-known fact, but emerging evidence highlights risks associated with excessive lowering. The use of lipid-lowering agents to reduce cardiovascular risk is well-established; however, excessive cholesterol reduction has raised concerns about the potential health implications of excessively low cholesterol levels. This review explores the "cholesterol paradox," highlighting the dual nature of cholesterol as both a contributor to cardiovascular risk and an essential component for cellular integrity, hormone synthesis, brain function, and vitamin D production. A systematic search of PubMed, Google Scholar, JAMA, and Cochrane Library for eligible studies was conducted from 1980 until December 1, 2024. Evidence suggests that excessively low cholesterol levels may impair cell membrane integrity, neurotransmission, and immune function. This review underscores the need for balanced clinical approach to cholesterol management rather than solely aiming for aggressive reduction, ensuring both cardiovascular protection and broader systemic health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.