ArticleJournal of materials chemistry. B2026
Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats.
Gopal Agarwal, Allison Campbell, Arun Wanchoo, Daniel Plant, Izabela Zmirska, Jacob Fuhr, Prodip Bose, Gregory A Hudalla, Benjamin G Keselowsky, Christine E Schmidt
Erratum issuedAbstract read
In one paragraphArticle in Journal of materials chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Gopal AgarwalJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.ORCID http://orcid.org/0000-0002-7906-9611 Allison CampbellJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.ORCID http://orcid.org/0009-0005-7808-590X Arun WanchooJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.
Daniel PlantDepartment of Anesthesiology and Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA.
Izabela ZmirskaJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.
Jacob FuhrJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.
Prodip BoseDepartment of Anesthesiology and Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA.
Gregory A HudallaJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.ORCID http://orcid.org/0000-0003-2259-0809 Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.ORCID http://orcid.org/0000-0001-6474-7769 Christine E SchmidtJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, 32610, USA. bkeselowsky@bme.ufl.edu.
Funding
Diversity Supplement: Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion InjuryR01DK129690 · NIDDK · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE, ZARRINPAR, ALI · 2022 to 2025
$2.7MFunctionalized Enzyme Treatments for Dual-Targeting of Inflammation in Spinal Cord InjuryR21NS123596 · NINDS · UNIVERSITY OF FLORIDA · PI KESELOWSKY, BENJAMIN GEORGE, SCHMIDT, CHRISTINE E · 2021 to 2021
$410kMentoring Patient-Oriented Research in Immune Response in TransplantationK24AI187634 · NIAID · UNIVERSITY OF FLORIDA · PI ALI ZARRINPAR · 2025 to 2026
$251kNIAID NIH HHS K24 AI187634NIDDK NIH HHS R01 DK129690NINDS NIH HHS R21 NS123596
6 · The paper itselfAbstract
Traumatic spinal cord injury (SCI) results in excessive neuroinflammation characterized by secondary injury cascades, which in turn hinders axonal regeneration and impairs functional recovery. Here, we sought to deliver an anti-inflammatory enzyme, indoleamine 2,3 dioxygenase (IDO), as a potential therapy to reduce the inflammatory burden and foster improved neural regeneration following SCI. IDO has previously been shown to decrease local inflammation in periodontal and osteoarthritis models; however, its potential to mitigate neuroinflammation is still unexplored. In this study, we evaluated the therapeutic potential of an engineered form of human IDO fused to galectin-3 (IDO-Gal3). Galectin-3 binds to extracellular glycans, including those on proteoglycans known to be overexpressed at the injury site, prolonging local retention of the enzyme. This fusion construct was delivered
Indexed as
Galectin 3HydrogelsIndoleamine-Pyrrole 2,3,-DioxygenaseNeuroinflammatory DiseasesSpinal Cord InjuriesAnimalsFemaleHumansInflammationInjectionsNeuronsRatsRats, Sprague-DawleyGalectin 3HydrogelsIndoleamine-Pyrrole 2,3,-Dioxygenase
Identifiers
PMID41783955
PMCPMC13343502
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