Physical Mechanisms of an Unconventional Green Fluorescent Protein Indicator for Chloride.

Mfon V Sunday, Ke Ji, Derik A Adams, Weicheng Peng, Sheel C Dodani, Alice R Walker

Abstract read

In one paragraph

Article in The journal of physical chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mfon V SundayDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID 0009-0002-1704-7780

Ke JiDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0002-0085-9646

Derik A AdamsDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.

Weicheng PengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.

Sheel C DodaniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0003-0271-6080

Alice R WalkerDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID 0000-0002-8617-3425

Funding

Optical Imaging Tools for Elucidating the Roles of Anions and Anionic Modifications in Cellular SignalingR35GM128923 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Sheel Dodani · 2018 to 2026

$3.4M

NIGMS NIH HHS R35 GM128923

6 · The paper itself

Abstract

Fluorescent proteins bearing an intrinsic tripeptide chromophore exhibit diverse, tunable photophysical features that are exceptional for biosensing applications. However, atomic-level details of these sensing mechanisms are obscured experimentally, particularly as protein motions, including the chromophore, cannot be divined from the structure alone. Molecular dynamics (MD) simulations can bridge this gap, providing a landscape of global and local protein motions with resolution to key amino acids connected to function and potential for engineering. In this study, we uncover that the green fluorescent protein from the jellyfish

Indexed as

ChloridesGreen Fluorescent ProteinsAnimalsHydrogen-Ion ConcentrationHydrozoaMolecular Dynamics SimulationScyphozoaChloridesGreen Fluorescent Proteins

Identifiers

PMID41784459

DOI10.1021/acs.jpcb.5c08244

PMCPMC13004581

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.