Evidence map›Paper›PMID 41784493›Full record

ArticleMicrobiology spectrum2026

Verapamil HCl demonstrates antiviral activity against porcine reproductive and respiratory syndrome virus by regulating Ca

Tongtong Wang, Li Chen, Jiamin Fan, Zhiqiang Yan, Wenjing Chen, Yuyu Zhang, Yulin Xu, Qinghai Ren, Shujing Wang, Siding Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tongtong Wang *Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.ORCID 0009-0007-3999-3184
Li Chen *College of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Jiamin Fan *College of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Zhiqiang YanCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Wenjing ChenCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Yuyu ZhangKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.
Yulin XuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.
Qinghai RenCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Shujing WangCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Siding LiuCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Liangliang LiCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.ORCID 0000-0001-5431-9103
Yubao LiCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.ORCID 0000-0002-8533-5015
Jiaqiang WuKey Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, China.ORCID 0000-0001-9160-9951

Funding

China Postdoctoral Science Foundation 2025M773037Natural Science Foundation of Shandong Province ZR2024MC162Project of Shandong Province Higher Educational Science and Technology Program 2022KJ287
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) poses a major challenge to swine health, impairing reproductive performance and causing respiratory disorders in pigs. Thus, it creates a considerable economic burden for the global pig production industry. Current prevention and control strategies for PRRSV remain largely ineffective, necessitating the development of novel antiviral drugs. In the current study, we examined how Verapamil HCl could potentially protect host cells against PRRSV infection using both cellular and animal models. Further, we explored the molecular mechanisms underlying these potential anti-PRRSV effects. We discovered that Verapamil HCl suppresses PRRSV infection in MARC-145 cells, PK-15 IMPORTANCE: Verapamil HCl is known to suppress infections caused by several viruses, including respiratory syncytial virus, bovine herpesvirus 1, and SARS-CoV-2. However, the potential anti-PRRSV mechanisms of Verapamil HCl remain unknown. This study demonstrates that Verapamil HCl exerts anti-PRRSV effects by attenuating the Ca

Indexed as

Antiviral AgentsCalciumInterferon Type IPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusVerapamilAnimalsCell LineHeme Oxygenase-1Macrophages, AlveolarNF-E2-Related Factor 2Signal TransductionSwineVirus ReplicationAntiviral AgentsCalciumHeme Oxygenase-1Interferon Type INF-E2-Related Factor 2VerapamilcalciumIFN responsep38/Nrf2/Keap1/HO-1PRRSV inhibitorVerapamil HCl

Identifiers

PMID41784493
PMCPMC13055301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.