Evidence map›Paper›PMID 41784996›Full record

ArticleAnnals of clinical and translational neurology2026

Minimally Clinically Important Difference of the Clinical Assessment Scale in Autoimmune Encephalitis.

Yihui Goh, Yoon Hee Shin, Soo Hyun Ahn, Su Yee Mon, Soo Jean Shin, Woo-Jin Lee, Yoonhyuk Jang, Myoung-Jin Jang, Soon-Tae Lee

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In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yihui GohDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Yoon Hee ShinDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Soo Hyun AhnDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Su Yee MonDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Soo Jean ShinDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Woo-Jin LeeDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si, South Korea.
Yoonhyuk JangDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Myoung-Jin JangMedical Research Collaborating Center, Seoul National University Hospital, Seoul, South Korea.
Soon-Tae LeeDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.ORCID 0000-0003-4767-7564

Funding

Korea Health Industry Development Institute RS-2023-00266044Ministry of HealthMinistry of Science and ICT, South Korea RS-2025-00519112National Research Foundation
6 · The paper itself

Abstract

The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) tracks disease severity in autoimmune encephalitis (AE), but no threshold for significant change exists. We aimed to determine the minimally clinically important difference (MCID) for CASE. Using our AE cohort, receiver operating characteristic analyses were anchored to ≥ 1-point improvement in mRS over 3-month intervals. Among 222 AE patients (65 NMDAR, 49 LGI1, and 108 seronegative AE), a 30% CASE reduction showed good discriminatory performance for mRS improvement in the first 6 months, particularly in NMDAR and seronegative subgroups. A 30% CASE reduction may standardize AE response definitions.

Indexed as

EncephalitisHashimoto DiseaseSeverity of Illness IndexAdultAgedFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiddle AgedYoung AdultIntracellular Signaling Peptides and ProteinsLGI1 protein, humanautoimmune encephalitisclinical assessment scale in autoimmune encephalitisoutcomes

Identifiers

PMID41784996
PMCPMC13251426

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.