ArticleGlobal spine journal2026
CT-Based Bone Habitat Radiomics for Predicting Risk of Vertebral Fracture in Older Adults: A Longitudinal Study.
Article in Global spine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Study design/settingRetrospective longitudinal study.PurposeOsteoporotic vertebral fractures (OVF) are common in middle-aged and elderly populations. However, few studies have predicted the risk of OVF from the perspective of the bone heterogeneity. This study conducted a longitudinal study to predict the risk of OVF in individuals over 50 years old based on habitat radiomics which can quantify heterogeneity of vertebral trabecular bone.MethodsIndividuals aged over 50 years who had not experienced OVF and underwent CT scans between 2016 and 2023 were enrolled and followed up until 2024. During the follow-up period, 107 cases developed new OVF, and 270 individuals without fractures were selected as the control group. Radiomic features of each pixel within the vertebra were extracted, and the optimal segmentation of vertebral sub-regions was determined using the K-means unsupervised clustering method.ResultsThe habitat radiomics model significantly outperformed the CT value model (AUC = 0.702, DeLong test
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