Evidence mapPaperPMID 41785144Full record

ArticlePsychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors2026

Assessing measurement bias in substance use disorder criteria associated with childhood adversity and genetic liability.

Christal N Davis, Jackson SooHoo, Angela Han, Joel Gelernter, Richard Feinn, Henry R Kranzler

Abstract read
In one paragraph

Article in Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christal N DavisMental Illness Research, Education, and Clinical Center, Crescenz Veterans Affairs Medical Center.ORCID 0000-0003-3974-5598
Jackson SooHooDepartment of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine.ORCID 0009-0000-0233-2250
Angela HanDepartment of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine.
Richard FeinnDepartment of Medical Sciences, Frank H. Netter School of Medicine, Quinnipiac University.
Henry R KranzlerMental Illness Research, Education, and Clinical Center, Crescenz Veterans Affairs Medical Center.

Funding

Combining Pregabalin with Lofexidine: Can it Increase the Success of Transition to Naltrexone?UG3DA049694 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KAMPMAN, KYLE MATTHEW, WOODY, GEORGE EDWARD · 2019 to 2019
$4.1M
Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
National Institutes of Health; National Institute on Alcohol Abuse and AlcoholismNational Institutes of Health; National Institute on Drug AbuseNIAAA NIH HHS R01 AA030056NIDA NIH HHS UG3 DA049694University of Pennsylvania; Center for Undergraduate Research & FellowshipsUS Department of Veterans Affairs; Office of Academic AffiliationsVeterans Integrated Service Network 4 Mental Illness Research, Education, and Clinical Center
6 · The paper itself

Abstract

objectiveThe diagnosis and severity of substance use disorders (SUDs) are classified by the number of criteria endorsed. However, environmental and genetic factors may influence criterion endorsement. To evaluate this, we tested for differential item functioning of SUDs criteria by adverse childhood events (ACEs) and SUD polygenic scores.

methodIn 10,275 Yale-Penn participants (

resultsThere was variability in the difficulty and discrimination of SUD criteria. Many criteria discriminated less effectively among individuals with higher ACEs factor scores. Continued substance use despite physical/psychological problems (β = .08,

conclusionsFindings highlight the impact of ACEs on SUD assessment. Considering the relative weighting of criteria or developing screening procedures that consider subgroup-specific differences in symptom functioning may help address these biases. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Indexed as

Adverse Childhood ExperiencesSubstance-Related DisordersAdultBiasFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMarijuana AbuseMiddle AgedOpioid-Related Disorders

Identifiers

PMID41785144
PMCPMC12970586

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.