ArticlePloS one2026
Exploring the effects of IFN-τ on LPS-induced endometritis in cows based on transcriptomics.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometritis in dairy cows is a common reproductive disease that severely affects reproductive performance and milk production, resulting in significant economic losses. Lipopolysaccharide (LPS) as a PAMP capable of inducing inflammatory responses in the endometrium through the NF-κB pathway. Interferon-tau (IFN-τ) is a type I interferon with significant anti-inflammatory properties. Currently, transcriptomics sequencing technology has gradually become an attractive tool for studying such diseases. This study established an inflammatory model of bovine endometrial cells (BENDs) using LPS induction and employed RNA-seq technology to investigate the expression profiles of mRNAs in BENDs from the Control group (C), the LPS-treated group (L), and the IFN-τ + LPS-treated group (F). The results showed that there were 109, 1109, and 962 Differentially Expressed mRNAs (DEmRNAs) in the C vs L, C vs F, and L vs F. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that these DEmRNAs were mainly involved in the regulation of host immune responses (e.g., NOD-like receptor signaling pathway, IL-17 signaling pathway and RIG-I-like receptor signaling pathway, NF-kappa B signaling pathway), signal transduction molecules and interactions (e.g., Cytokine-cytokine receptor interaction; Cell adhesion molecules), metabolic process (e.g., Glycosphingolipid biosynthesis-lacto and neolacto series) and Antigen processing and presentation, Complement and coagulation cascades, Th17 cell differentiation, etc. biological process. This study not only elucidates the molecular mechanisms by which BENDs respond to microbial invasion but also reveals the specific regulatory network through which IFN-τ exerts its anti-inflammatory effects via multiple synergistic pathways. It provides crucial theoretical support for the clinical application of interferon therapy in treating endometritis, demonstrating significant research value and promising applications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.