Evidence map›Paper›PMID 41785322›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Direct evidence of acid-driven protein desolvation.

Farzad Hamdi, Ioannis Skalidis, Inken Kaja Schwerin, Jaydeep Belapure, Dmitry A Semchonok, Fotis L Kyrilis, Christian Tüting, Johannes Müller, Georg Künze, Panagiotis L Kastritis

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farzad Hamdi *Department of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-2155-5000
Ioannis Skalidis *Department of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-3077-9014
Inken Kaja Schwerin *Institute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0002-8645-518X
Jaydeep BelapureDepartment of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Dmitry A SemchonokDepartment of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0003-1622-9443
Fotis L KyrilisDepartment of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.
Christian TütingDepartment of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0001-6209-4012
Johannes MüllerInstitute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale) D-06120, Germany.ORCID 0000-0002-7493-1532
Georg KünzeInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-1799-346X
Panagiotis L KastritisDepartment of Integrative Structural Biochemistry, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Halle/Saale 06120, Germany.ORCID 0000-0002-1463-8422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water and its ability to modulate the protonation states of biomolecules govern the physical chemistry of life, dictating their metabolic functions. However, how amino acid protonation alters protein hydration and solubility is an open question since Kuntz and Kauzmann proposed p

Indexed as

AcidsProteinsWaterAmino AcidsCryoelectron MicroscopyHydrogen-Ion ConcentrationMolecular Dynamics SimulationProtein ConformationSolubilitySolventsAcidsAmino AcidsProteinsSolventsWatercryo-EMmolecular dynamicsprotein hydrationwater molecules

Identifiers

PMID41785322
PMCPMC12974452

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.