Evidence map›Paper›PMID 41785822›Full record

ArticlePsychiatry research. Neuroimaging2026

Resting-state functional connectivity in HIV - Findings from the ENIGMA HIV working group.

Aliaa Ibnidris, Jonathan Ipser, Talia M Nir, Ronald A Cohen, Thomas Ernst, Kalpana J Kallianpur, Eric C Porges, Heather J Zar, Paul M Thompson, Steven Shoptaw and 3 more

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In one paragraph

Article in Psychiatry research. Neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aliaa IbnidrisDepartment of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Electronic address: aliaa.ahmedibnidriselsiddig@uct.ac.za.
Jonathan IpserDepartment of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Talia M NirImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, United States.
Ronald A CohenCenter for Cognitive Aging and Memory, Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States.
Thomas ErnstDepartment of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Kalpana J KallianpurHawaii Center for AIDS, University of Hawaii, Honolulu, Hawaii, United States; Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii, Honolulu, Hawaii, United States.
Eric C PorgesCenter for Cognitive Aging and Memory, Department of Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States.
Heather J ZarDepartment of Paediatrics & Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa; South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, Department of Paediatrics, University of Cape Town, Cape Town, South Africa.
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, United States.
Steven ShoptawDepartment of Family Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, United States; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA, United States.
Dan J SteinDepartment of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
Linda ChangDepartment of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States; Department of Diagnostic Radiology & Nuclear Medicine and Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Neda JahanshadImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, United States.

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

backgroundPrevious studies demonstrated a link between disrupted resting-state functional connectivity (RSFC) in the Default Mode Network (DMN) and cognitive impairment in people with HIV (PWH). Rs-fMRI studies to date have not investigated DMN connectivity with other brain regions that are typically implicated in HIV (i.e., striatum), and how this is related to cognition. We hypothesized that intra-DMN RSFC and DMN-striatal RSFC will be significantly different between PWH and HIV-negative controls (HC), and that these alterations are associated with cognition.

methodsWe used the posterior cingulate cortex (PCC) as the main node of the DMN and calculated its RSFC to other DMN regions for intra-DMN RSFC and to striatum. We performed an Analysis of Covariance to examine group differences in RSFC between PWH and HC. We conducted linear regression modelling to test the association of cognitive performance and RSFC in PWH.

resultsThere were no statistically significant differences between PWH and HC in PCC-ROI RSFC. However, in PWH, we found that higher education and greater RSFC of PCC- right hippocampus were associated with better performance in working memory (p = 0.0007 and 0.03).

conclusionOur results suggest that altered intra-DMN RSFC may contribute to cognitive dysfunction observed in PWH.

Indexed as

Cognitive DysfunctionConnectomeCorpus StriatumDefault Mode NetworkGyrus CinguliHIV InfectionsAdultFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedDMN connectivityNeurocognitive impairmentNeuroHIVResting-state fMRI

Identifiers

PMID41785822
PMCPMC13286686

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.