Evidence map›Paper›PMID 41786764›Full record

ArticleNPJ science of food2026

Gut microbiome modulation by cricket, pea, and whey protein using the SHIME in vitro simulator.

Irene Franciosa, Gabriele Castelnuovo, Carolina Cantele, Vladimiro Cardenia, Simona Bo, Valentina Ponzo, Ilaria Goitre, Erica Pontonio, Dora Tortarolo, Michela Verni and 5 more

Abstract read
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In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Irene FranciosaDepartment of Agricultural, Forest and Food Sciences, University of Torino, Torino, Italy.
Gabriele CastelnuovoDepartment of Medical Science, University of Torino, Torino, Italy.
Carolina CanteleDepartment of Agricultural, Forest and Food Sciences, University of Torino, Torino, Italy.
Vladimiro CardeniaDepartment of Agricultural, Forest and Food Sciences, University of Torino, Torino, Italy.
Simona BoDepartment of Medical Science, University of Torino, Torino, Italy.
Valentina PonzoDepartment of Medical Science, University of Torino, Torino, Italy.
Ilaria GoitreDepartment of Medical Science, University of Torino, Torino, Italy.
Erica PontonioDepartment of the Soil, Plant and Food Science DiSSPA, University of Bari Aldo Moro, Bari, Italy.
Dora TortaroloDepartment of Computer Science, University of Torino, Torino, Italy.
Michela VerniDepartment of Human Science and Quality of Life Promotion, San Raffaele University, Rome, Italy.
Elisabetta BugianesiDepartment of Medical Science, University of Torino, Torino, Italy.
Francesca CorderoDepartment of Computer Science, University of Torino, Torino, Italy.
Marco BeccutiDepartment of Computer Science, University of Torino, Torino, Italy.
Luca CocolinDepartment of Agricultural, Forest and Food Sciences, University of Torino, Torino, Italy.
Ilario FerrocinoDepartment of Agricultural, Forest and Food Sciences, University of Torino, Torino, Italy. Ilario.ferrocino@unito.it.

Funding

NODES funding from the MUR - M4C2 1.5 of PNRR, funded by the European Union - NextGenerationEU, Mission 4 Component 1.5 - ECS00000036 D17G22000150001
6 · The paper itself

Abstract

Entomophagy is increasingly popular, and Acheta domesticus offers an ecologically sustainable protein alternative, but the effects on the human gut microbiome need further investigation. In this study, we investigated the impact of the intake of three isolated proteins: pea (plant), whey (animal), and cricket (insect) on gut microbiome of a single-donor using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®). Cricket protein intake was associated with potential beneficial taxa such as Bifidobacterium and Lactobacillus, genes related to vitamin biosynthesis and bacteriocin transport, and short and medium-chain fatty acids. Pea protein intake was associated with Faecalibacterium and Slackia, while whey protein with Butyricimonas and Lactobacillus. Metagenomic analysis revealed that pea intake led to increased lysine degradation genes, promoting SCFAs production. Each protein has its own unique characteristics that may contribute positively to gut health. Specifically, cricket protein intake appears to have beneficial effects, promoting the growth of potentially beneficial taxa and enhancing short-chain fatty acid production. The results of this study indicate that cricket protein does not exhibit any detrimental effects compared to pea and whey proteins.

Identifiers

PMID41786764
PMCPMC13086921

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.