ArticleExperimental & molecular medicine2026
The asymmetrical ROS-METTL3-ESR1 axis in paraspinal muscle progenitor cells determines the progression of adolescent idiopathic scoliosis.
Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Vitamin E-Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis-Generating Multi-Omics Analysis.Food science & nutrition · 2026Article
- Outcomes of high-compliance bracing in patients with severe adolescent idiopathic scoliosis declining operative intervention.Frontiers in pediatrics · 2026Article
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9 authors.
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Abstract
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, yet its precise etiology remains elusive. Our previous research highlighted the pivotal role of the asymmetrical ESR1 expression of paraspinal muscle stem/progenitor cells in the progression of AIS. However, the widespread distribution of ESR1 in various organs and tissues limits its safety and efficacy as a therapeutic target. Therefore, it is imperative to investigate the regulatory mechanisms governing the asymmetric ESR1 expression in paraspinal muscle stem/progenitor cells to identify safer and more effective treatment strategies for AIS. Here we discovered elevated levels of reactive oxygen species (ROS) in the concave paraspinal muscles of patients with AIS. The increased ROS decreased the expression of m
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