ArticleCommunications biology2026
Thioredoxin and its partner protein are essential for zoospore flagellar formation in Actinoplanes missouriensis.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The filamentous bacterium Actinoplanes missouriensis produces flagellated spores, which become zoospores after release, in sporangia. However, the regulatory mechanism of spore flagellation remains unclear. Here, we report that a thioredoxin, TrxA, and its partner protein, PtxA, are crucial for flagellation. Most spores of trxA and ptxA null mutants are non-flagellated, despite normal transcription of flagellar genes. Gene complementation tests show that the EKVEQ motif in TrxA, but not thioredoxin activity, is indispensable for flagellation. Analysis of motile suppressor strains obtained from both mutants reveals that ClpC, a chaperone component of the Clp protease complex, and FliR, a flagellar secretion gate component, are involved in the regulation of flagellation. TrxA and PtxA interact with each other and bind to ClpC in bacterial two-hybrid analysis. Based on the experimental results, we propose a working model for flagellar assembly control by TrxA and PtxA in A. missouriensis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.