ArticleThe journal of headache and pain2026
Altered dorsal anterior insula functional connectivity underlying abnormal interoceptive accuracy awareness in migraine without aura.
Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Kappa opioid receptor availability correlates with depressive symptom burden in chronic migraine: a preliminary investigation.The journal of headache and pain · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAbnormal interoception is increasingly recognized as a key feature of migraine. The dorsal anterior insula (dAI) is hypothesized to play a central role in interoceptive processing, yet the neural mechanisms underlying this abnormality remain unclear. We aimed to investigate interoceptive disturbances in migraine and to clarify the role of insula dysfunction, specifically dAI functional connectivity, in underlying these interoceptive alterations and potentially contributing to the pathophysiology of migraine.
methodsWe recruited 29 patients with migraine without aura and 32 matched healthy controls. All participants completed evaluations of interoceptive accuracy and resting-state functional magnetic resonance imaging scans. We applied a multivariate seed-based connectivity approach to examine the direct connectivity of the bilateral dAI and its link to interoceptive awareness in migraine patients. We conducted a simple mediation analysis to determine whether specific dAI connectivity mediated variations in interoceptive awareness across groups. Finally, serial multiple mediation analysis was applied to explore whether these effects were conveyed via subjective or objective accuracy metrics.
resultsMigraine patients showed significantly enhanced interoceptive accuracy awareness compared with controls. Across all participants, this awareness was positively associated with functional connectivity from the right dAI to the bilateral precentral gyrus (PreCG). Crucially, this specific right dAI-bilateral PreCG connectivity was markedly enhanced in migraine patients. Simple mediation results indicated that increased dAI connectivity substantially mediated the group difference in interoceptive accuracy awareness. Serial multiple mediation analysis revealed that this effect was predominantly driven by objective interoceptive processing.
conclusionsThe observed altered dAI connectivity and its relationship with interoceptive awareness suggest that dysfunctions in interoceptive processes, particularly within the dAI-PreCG network, may be integral to the neuropathology of migraine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.