ArticleBMC oral health2026
Bioactive photo-crosslinkable hydrogel based on decellularized dental pulp matrix for functional pulp regeneration.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dental pulp extracellular matrix (DPEM), as a naturally derived scaffold material for dental pulp regeneration, exhibits excellent biocompatibility. This study aims to develop a novel photo-cross-linked hydrogel composed of methacry- lated gelatin (GelMA) loaded with DPEM for application in pulp regeneration. In vitro experiments demonstrated that the GelMA–DPEM hydrogel, fabricated by mixing a 10 mg mL − 1 DPEM solution with a 10% (w/v) GelMA solution at a ratio of 1:1, formed a stable cross-linked network with a swelling ratio of approx- imately 343%. Frequency-sweep rheology indicated that incorporation of DPEM increased the storage modulus of the hydrogel compared with GelMA alone, and the composite hydrogel significantly promoted cell migration and angiogenic ca- pacity. RT–qPCR analysis revealed that the GelMA–DPEM hydrogel markedly upregulated the expression levels of neuroepithelial stem cell protein (Nestin), dentin sialophosphoprotein (DSPP), platelet endothelial cell adhesion molecule-1 (CD31), and runt-related transcription factor 2 (Runx2). Moreover, ectopic trans- plantation in nude mice indicated that, when combined with human dental pulp stem cells (hDPSCs), the GelMA–DPEM hydrogel preserved the DPEM’s capa- bility to support the formation of a cell-rich, vascularized pulp-like tissue con- sisting of collagen-rich connective tissue and CD31-positive blood vessels. In conclusion, the GelMA–DPEM hydrogel showed favorable cytocompatibility and preliminary pro-angiogenic effects in vitro and supported pulp-like tissue forma- tion in a small-animal ectopic treated dentin matrix (TDM) model. These findings suggest that GelMA–DPEM is a promising candidate scaffold for dental pulp re- generation.
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