ArticleBMC surgery2026
Trend of C-Reactive protein after colorectal surgery may increase predictive value of anastomotic leak: a prospective analysis.
Article in BMC surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly diagnosis of anastomotic leak (AL) after colorectal surgery is essential to reduce mortality and overall survival. C-reactive protein (CRP) is among the factors most significantly associated with infection and AL. Analysis of trend in CRP levels could be crucial in increasing its predictive value.
aimsWe performed a prospective evaluation on a cohort of patients undergoing colorectal resection for cancer, comparing CRP values on the first postoperative days to assess delta CRP in relation to identification of AL.
methodsOur prospective evaluation considered cases of elective colorectal surgery for cancer, enrolled by two high-volume centers from January 2021 to June 2024. We considered 2 groups: leakage (L group) and non-leakage (NL group). Evaluation of CRP levels on POD 1 and 3 was recorded, analyzing linear difference (delta CRP). Patients with suspicion of AL underwent postoperative imaging.
resultsFinal analysis was conducted on 320 patients. Among these, 13 (4.1%) experienced an AL. CRP levels on POD1 and POD3, and delta CRP variables demonstrated AUC values of 0.692, 0.902, and 0.969, respectively, indicating that delta CRP is the most predictive measure compared to individual CRP values. Delta CRP reported a specificity of 0.964 and a sensitivity of 0.923.
conclusionsOur data confirmed that high NPV of postoperative CRP trend was able, already on POD3, to rule out anastomotic complications. CRP trend between POD1 and POD3 seems to increase the sensitivity and specificity of this biochemical marker, which should be confirmed by larger cohorts, considering this a pilot study.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.