Evidence map›Paper›PMID 41787744›Full record

ArticleAutophagy2026

Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy.

Alice Viotti, Claudia Molinaro, Jessica Perego, Andrea Fossaghi, Chiara Parravicini, Eliana Lauranzano, Antonella Borreca, Marco Piccoli, Luigi Anastasia, Susanna Manenti and 7 more

Abstract read
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alice ViottiNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Claudia MolinaroNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jessica PeregoNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea FossaghiNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Chiara ParraviciniDipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di, Milano, Italy.
Eliana LauranzanoPharmacology and Brain Pathology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Antonella BorrecaPharmacology and Brain Pathology Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Marco PiccoliStem Cells for Tissue Engineering Lab, IRCCS Policlinico, San Donato, San Donato M.se, Italy.
Luigi AnastasiaStem Cells for Tissue Engineering Lab, IRCCS Policlinico, San Donato, San Donato M.se, Italy.
Susanna ManentiClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Annamaria FinardiClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alessandra MandelliClinical Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Michela MatteoliConsiglio Nazionale delle Ricerche, URT c/o IRCCS Humanitas Research Hospital, Neuroscience Institute, Milan, Italy.
Ivano EberiniDipartimento di Scienze Farmacologiche e Biomolecolari "Rodolfo Paoletti", Università degli Studi di, Milano, Italy.
Paola PaninaNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gianvito MartinoNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luca MuzioNeuroimmunology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-1068-865X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a severe medical condition characterized by diminished blood flow to the brain, resulting in a shortage of oxygen and nutrients. During ischemia, neurons surrounding the cerebral infarct initiate macroautophagy. However, the implications of this activation for neuronal cell survival are still debated. The identification of new autophagy modulators could aid in understanding autophagy's role in brain ischemia and lay the groundwork for innovative therapeutic strategies aimed at minimizing brain damage in this life-threatening neurological emergency. In this study, we developed a robust and sensitive screening platform to identify autophagy modulators from a library of bioactive compounds. Selected compounds underwent further

Indexed as

AutophagyBrain IschemiaDuloxetine HydrochlorideAnimalsHumansMiceMice, Inbred C57BLMice, TransgenicNeuronsNeuroprotective AgentsDuloxetine HydrochlorideNeuroprotective AgentsBrain ischemiaduloxetinemacroautophagySNRITRPM2

Identifiers

PMID41787744
PMCPMC13185465

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.