Evidence map›Paper›PMID 41787829›Full record

Trial reportMolecular nutrition & food research2026

Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity.

Maria J Sholola, Jenna Miller, Emma A Bilbrey, Janet A Novotny, David M Francis, Thomas A Mace, Jessica L Cooperstone

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria J ShololaDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.ORCID 0009-0000-8356-7800
Jenna MillerDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Emma A BilbreyDepartment of Horticulture and Crop Science, The Ohio State University, Columbus, Ohio, USA.
Janet A NovotnyBeltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, USA.
David M FrancisDepartment of Horticulture and Crop Science, The Ohio State University, Wooster, Ohio, USA.
Thomas A MaceDivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Jessica L CooperstoneDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-7920-0088

Funding

A dietary intervention clinical trial to reduce inflammation and improve outcomes in chronic pancreatitisR01DK138871 · NIDDK · OHIO STATE UNIVERSITY · PI Jessica Cooperstone, Philip A. Hart · 2025 to 2026
$608k
Foods for Health Initiative at the Ohio State UniversityLisa and Dan Wampler Endowed Fellowship for Foods and Health ResearchNIH HHS R01DK138871United States Department of Agriculture 2020-38420-30723United States Department of Agriculture NIFA AFRI 2018-67017-27519United States Department of Agriculture OHO01470United States Department of Agriculture OHO01538United States Department of Agriculture OHO01563
6 · The paper itself

Abstract

Chronic, low-grade inflammation is a hallmark of many noncommunicable diseases. Diets enriched with tomatoes and soy are associated with better health outcomes in inflammation-related illnesses, with lycopene and isoflavones considered key bioactive components, respectively. On the basis that whole food combinations may exert greater effects than isolated phytochemicals, we examine the anti-inflammatory and metabolic effects of tomato-soy juice compared to a low carotenoid tomato juice control in obesity. Twelve healthy adults with obesity were provided either tomato-soy juice (54 mg lycopene/d, 189.9 mg isoflavones/d) or a low carotenoid tomato juice (no isoflavones) daily for 4 weeks, then crossed over to the other treatment following a washout period. Plasma carotenoids, cytokines, and the urine metabolome were measured pre- and post-interventions. Plasma lycopene significantly increased by 2.48-fold after tomato-soy intake. IL-5, IL-12p70, and GM-CSF significantly decreased (p < 0.05), and TNF-α trended downward (p = 0.052) following tomato-soy. Soy isoflavone metabolites primarily distinguished post-tomato-soy urine profiles. Both interventions induced some shared metabolomic changes in the urine, indicating tomato-driven effects independent of lycopene. Overall, tomato-soy intake reduced pro-inflammatory cytokines and altered urine metabolomic profiles in obesity, supporting future studies using this functional food product for other inflammation-related conditions.

Indexed as

Fruit and Vegetable JuicesGlycine maxInflammationMetabolomeObesitySolanum lycopersicumAdultCarotenoidsCross-Over StudiesCytokinesFemaleHumansIsoflavonesLycopeneMaleMiddle AgedCarotenoidsCytokinesIsoflavonesLycopeneinflammationmetabolomicsobesitytomato‐soyUHPLC‐MS

Identifiers

PMID41787829
PMCPMC12963818

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.