ArticleBiomedical chromatography : BMC2026
Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology.
Article in Biomedical chromatography : BMC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Influence ofMetabolites · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti-inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q-markers) remains limited, underscoring the need to analyze its chemical composition to enable effective quality control. A high-performance liquid chromatography (HPLC) fingerprint method was developed for 21 VTH batches in order to identify the common peaks of 23 flavonoids and esculetin, which were verified using liquid chromatography-mass spectrometry (LC-MS) and reference standards. In this study, chemometric methods were employed to differentiate samples from four geographical origins and to screen for differential components. In addition, a thorough examination of virtual target prediction in network pharmacology, in conjunction with molecular docking validation, has identified Q-markers with potential antiasthmatic effects. A group of six representative Q-markers (including kaempferol 3-O-sophorosyl-7-O-glucoside, esculetin, kaempferol 3-O-rutinosyl-7-O-glucoside, nicotiflorin, narcissoside, and astragalin) was selected for the purpose of developing a method to quantitatively analyze these components simultaneously in VTH samples. This study provides important references for the comprehensive quality control of VTH and establishes the foundation for researchers to explore the chemical basis and mechanisms of action of VTH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.