ReviewNeurophotonics2026
Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.
Review in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Passive stabilization of low-power laser beams in soft hydrogels with parabolic-index profile for optogenetic neural stimulation: a phase analysis.RSC advances · 2026Article
- From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation ofFrontiers in synaptic neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past decade, techniques enabling bidirectional modulation of neuronal activity with single-cell precision have rapidly advanced in the form of two-photon optogenetic stimulation. Unlike conventional electrophysiological approaches or one-photon optogenetics, which inevitably activate many neurons surrounding the target, two-photon optogenetics can drive hundreds of specifically targeted neurons simultaneously, with stimulation patterns that can be flexibly and rapidly reconfigured. In this review, we trace the development of two-photon optogenetic stimulation, focusing on its progression toward implementations in large field of view two-photon microscopes capable of targeted multi-neuron control. We highlight three principal strategies: spiral scanning, temporal focusing, and three-dimensional computer-generated holography, along with their combinations, which together provide powerful tools for causal interrogation of neural circuits and behavior. Finally, we discuss the integration of these optical technologies into brain-machine interfaces, emphasizing both their transformative potential and the technical challenges that must be addressed to realize their broader impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.