Evidence map›Paper›PMID 41788309›Full record

ArticleFrontiers in cell and developmental biology2026

A novel culture flask for clinostat-based simulation of extraterrestrial gravities.

Giovanni Perra, Giacomo Fais, Debora Dessì, Alessandro Concas, Paolo Follesa, Giacomo Cao, Nicola Lai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanni Perra *Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Giacomo Fais *Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Debora DessìDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Alessandro ConcasDepartment of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Paolo FollesaInterdepartmental Centre of Environmental Science and Engineering (CINSA), University of Cagliari, Cagliari, Italy.
Giacomo CaoDepartment of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Nicola LaiDepartment of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Conventional T-flasks (T-25) filled to capacity are frequently employed to minimize shear stress arising from fluid motion during ground-based microgravity simulations using a clinostat or random positioning machine (RPM). However, this approach can introduce confounding factors, such as hypoxia and CO Methods: We assessed the effects of static and rotational (i.e., microgravity) full-filled cultures including conventional T-25 and eighteen customized F-25 with different medium depths, gas exchange areas and membrane types on mitochondrial function of intact C Results: After 24 h, conventional T-25 flasks, full-filled to height of H Discussion: The latter one provides a reproducible and relevant baseline, avoiding confounding factors related to O

Indexed as

bioengineered culture flasksclinostat high-resolution respirometrymitochondrial respirationrandom positioning machine (RPM)rotational culture systemssimulated microgravityspace exploration biotechnology

Identifiers

PMID41788309
PMCPMC12957785

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.