ArticleLe infezioni in medicina2026
Risk factors associated with carbapenem-resistant Enterobacterales infections in hospitalized patients: A case-control study.
Article in Le infezioni in medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Carbapenem-Resistant Enterobacterales (CRE) represent a critical public health threat. Methodology: A case-control study (27 cases; 193 controls) compared CRE versus Carbapenem-Susceptible Enterobacterales (CSE). Univariable and Multivariable Firth logistic regression was performed to adjust for small-sample bias. Results: In multivariable analysis, time to infection onset was the most consistent predictor of CRE (aOR: 1.08; 95% CI: 1.03-1.12; p=0.001). Other significant risk factors included chronic corticosteroid therapy (aOR: 43.10; 95% CI: 3.04-611.96; p=0.005), prior hospitalization (aOR: 14.52; 95% CI: 2.22-94.86; p=0.005), urinary catheter (aOR: 10.39; 95% CI: 2.20-49.00; p=0.003) and central venous catheterization (aOR: 13.46; 95% CI: 1.29-139.45; p=0.029). Nosocomial origin (aOR: 0.05; 95% CI: 0.003-0.86; p=0.039), and Internal Medicine management (aOR: 0.23; 95% CI: 0.06-0.94; p=0.041) showed protective associations. Conclusions: In this setting, the cumulative duration of healthcare exposure (time to infection onset) was the primary driver of CRE risk. However, these risk factors are highly context-dependent and vary across different populations and facilities. Therefore, these results cannot be generalized, highlighting the need for localized surveillance and further multicenter studies to understand regional resistance dynamics.
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