ArticleAddiction & health2025
Dose-Dependent Interaction Between Caffeine and Morphine in Analgesia in the Hot-Plate in Mice.
Article in Addiction & health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Combination analgesic therapy is a widely employed strategy for pain management worldwide. This study investigated the potential synergistic interaction between caffeine and morphine using the hot-plate test and isobolographic analysis in male NMRI mice. The interaction between caffeine and morphine in pain modulation was evaluated, and it was determined whether the combination produces a synergistic effect. Methods: Mice were treated with morphine (0.135, 1.25, 5, and 20 mg/Kg, s.c.) or caffeine (20, 40, 80, and 160 mg/Kg, i.p.) to obtain the ED50 values of each agent in the hot-plate test, then, an isobolographic analysis was used to evaluate the nature of interaction between the two drugs in mice. Findings: Morphine significantly increased pain thresholds in a dose-dependent manner (ED₅₀=2.49 mg/kg; Conclusion: A low dose of caffeine synergistically enhanced morphine-induced analgesia in the mouse hot-plate test; this effect was absent at a higher dose. Consequently, only low-dose caffeine administration effectively reduced the required dosage of morphine for acute pain management in the mouse hot-plate test.
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