Evidence map›Paper›PMID 41788589›Full record

ArticleJournal of ginseng research2026

Panaxadiol promotes angiogenesis against chronic cerebral hypoperfusion injury through the VEGF-A/p38 MAPK/Src signaling pathway.

Jun Xu, Meng Geng, Fang Tong, Yumeng Wang, Linhui Qin, Wenbo Zhao, Sijie Li, Xunming Ji, Changhong Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun XuBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Meng GengBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Fang TongBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Yumeng WangBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Linhui QinBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Wenbo ZhaoBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Sijie LiBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Xunming JiBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.
Changhong RenBeijing Key Laboratory of Hypoxia Conditioning Translation Medicine, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorder, Beijing, 100053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic cerebral hypoperfusion (CCH) is a major risk factor for vascular cognitive impairment (VCI). Angiogenesis plays a critical role in recovery from cerebrovascular disease. Panaxadiol (PD), a key active component of ginseng, exhibits neuroprotective effects; however, its role in promoting angiogenesis post-CCH remains unclear. Methods: A bilateral common carotid artery stenosis (BCAS) model was used to investigate the effects of PD (50 mg/kg, 30 days) on cerebral blood flow (CBF), cognitive function, and angiogenesis in mice. Cognitive tests included the Morris water maze (MWM), novel object recognition (NOR), and Y-maze. Vascular changes were assessed using laser speckle imaging and immunofluorescence. The effects of PD on endothelial cell (EC) functions were evaluated Results: PD increased CBF and alleviated cognitive impairment in BCAS mice. It enhanced neovascularization in the hippocampus and promoted ECs proliferation, migration, and tube formation Conclusion: PD ameliorates BCAS-induced cognitive deficits by promoting angiogenesis through the VEGF-A/p38 MAPK/Src signaling pathway, highlighting its potential as a therapeutic agent for CCH and VCI.

Indexed as

AngiogenesisChronic cerebral hypoperfusionGinsengPanaxadiolVEGF-A

Identifiers

PMID41788589
PMCPMC12959315

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.