Respiratory Microbiota Associations with Asthma Across American and Emirati Adults: A Comparative Analysis.

Ariangela J Kozik, Kyra Henderson, Laila Salameh, Bassam Mahboub, Mohammad T Al Bataineh, Yvonne J Huang

Abstract read

In one paragraph

Article in Applied microbiology (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ariangela J KozikDepartment of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.

Kyra HendersonDepartment of Molecular, Cellular, and Developmental Biology, College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.

Laila SalamehRashid Hospital, Dubai Health, Dubai P.O. Box 4545, United Arab Emirates.

Bassam MahboubRashid Hospital, Dubai Health, Dubai P.O. Box 4545, United Arab Emirates.

Mohammad T Al BatainehCollege of Medicine, Yarmouk University, Aydoun P.O. Box 566, Jordan.

Yvonne J HuangDepartment of Medicine, Division of Pulmonary/Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7497-6597

Funding

NIAID NIH HHS R01 AI129958

6 · The paper itself

Abstract

Background: Clinical features of asthma are associated with differences in the lower airway microbiome. However, knowledge is limited on whether airway microbiota composition differs between individuals residing in different geographic regions and if asthma-associated differences in lower airway microbiota are similar between distinct populations. Methods: Existing 16S rRNA gene sequence data, generated from sputum collected from adults with or without asthma ( Results: Differences in sputum bacterial composition, assessed by alpha- and beta-diversity measures, were associated with study site. Despite this, asthma-related differences were discerned in both cohorts. Specifically, sputum microbiota of asthmatic patients on ICS treatment displayed reduced bacterial phylogenetic diversity, compared to those not on ICS treatment ( Conclusions: Our findings suggest clinical factors associated with differences in the lower airway microbiome in asthma may transcend variation related to geographic area of residence.

Indexed as

airwayasthmageographymicrobiome

Identifiers

PMID41788690

DOI10.3390/applmicrobiol5030059

PMCPMC12959475

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.