ReviewFrontiers in immunology2026
The role of IL-11 in chronic diseases.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reticular Basement Membrane Remodelling Regulates Bronchial Epithelial Attachment, Barrier Integrity and Inflammatory Signalling in Asthma.Advances in respiratory medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Initially recognized for its role in hematopoiesis, Interleukin-11 (IL-11) is now understood to possess a wide spectrum of biological activities. It is involved in critical physiological processes, including immune cell differentiation, inflammatory response regulation, and tissue repair. Consequently, IL-11 is strongly implicated in the pathogenesis and progression of various chronic diseases. Discussion: This review examines the multifaceted biology of IL-11, detailing its discovery, molecular structure, and signaling mechanisms. We also explore its expression patterns across different tissues. A primary focus is placed on elucidating the critical role of IL-11 in the pathogenesis and progression of various chronic diseases. Furthermore, we discuss the emerging therapeutic potential of targeting the IL-11 pathway, evaluating evidence from both experimental models and clinical studies. Conclusion: By synthesizing current knowledge on the biological characteristics and disease associations of IL-11, this review aims to provide a comprehensive theoretical foundation for future research into its role in chronic diseases and its potential as a therapeutic target.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.