DoE-Based Optimization of a Photocatalytic C‑Alkylation Reaction in a 3D-Printed Photoreactor.

Dóra Richter, Gergő Gémes, Kinga I Hangya, Kinga Komka, Péter Kisszékelyi, Ágnes Gömöry, László Drahos, József Kupai

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Article in ACS sustainable chemistry & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Dóra RichterDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.

Gergő GémesDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.

Kinga I HangyaDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.

Kinga KomkaDepartment of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.

Péter KisszékelyiDepartment of Organic Chemistry, Faculty of Natural Sciences, Comenius University Bratislava, Mlynská dolina, Ilkovičova 6, SK-842 15 Bratislava, Slovakia.ORCID https://orcid.org/0000-0002-9529-0674

Ágnes GömöryMS Proteomics Research Group, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.

László DrahosMS Proteomics Research Group, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok körútja 2, H-1117 Budapest, Hungary.ORCID https://orcid.org/0000-0001-9589-6652

József KupaiDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary.ORCID https://orcid.org/0000-0002-4212-4517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photocatalysis provides a sustainable approach to chemical synthesis by enabling energy-efficient transformations under mild conditions. In this study, we present a comprehensive method that combines the development of photocatalytic reactions with process optimization, using a standardized 3D-printed photoreactor platform. We utilized the organophotocatalyst 4CzIPN to systematically optimize the visible-light-mediated carbon-carbon bond formation between the CH-acidic methyl cyanoacetate and 1,1-diphenylethylene. This optimization was performed through a 2

Indexed as

3D-printed photoreactor4CzIPNDoE optimizationenergy economy factorphotoredox catalysisradical C-alkylation

Identifiers

PMID41789175

DOI10.1021/acssuschemeng.5c11241

PMCPMC12958348

What Socratic holds

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LicenceCC BY

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