Evidence map›Paper›PMID 41789254›Full record

ArticleJournal of diabetes research2026

Shenqi Dihuang Decoction Attenuates ALOX5-Mediated Ferroptosis in Diabetic Nephropathy via AMPK/mTOR and TGF-

Li Zhao, Danna Zheng, Wenjuan Gu, Yanna Liu, Jinlong Lyu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li ZhaoUrology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.
Danna ZhengUrology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.ORCID https://orcid.org/0000-0001-6415-8585
Wenjuan GuUrology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.
Yanna LiuUrology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.
Jinlong LyuGeriatric Medicine Center, Department of Acupuncture and Massage, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China, hznu.edu.cn.ORCID https://orcid.org/0009-0009-3391-5796

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the underlying mechanisms about that Shenqi Dihuang decoction (SDD) attenuated diabetic nephropathy (DN), mice were fed on high-sugar and high-fat diet and treated with streptozotocin (STZ) to induce DN model, as well as HK-2 cells treated with D-glucose to establish a DN cell model. High-performance liquid chromatography (HPLC) analysis was carried out to excavate the chemical compositions existed in SDD. The network pharmacological analysis was performed to screen the key genes involved in SDD treating DN. Subsequently, the effects of SDD on ALOX5, ferroptosis- and AMPK/mTOR pathway-associated indices were examined. Finally, whether SDD attenuated ALOX5-mediated ferroptosis in DN via AMPK/mTOR and TGF-

Indexed as

AMP-Activated Protein KinasesArachidonate 5-LipoxygenaseDiabetic NephropathiesDrugs, Chinese HerbalFerroptosisTOR Serine-Threonine KinasesTransforming Growth Factor betaAnimalsCell LineDiabetes Mellitus, ExperimentalHumansKidneyMaleMiceMice, Inbred C57BLSignal TransductionAMP-Activated Protein KinasesArachidonate 5-LipoxygenaseDrugs, Chinese HerbalmTOR protein, mouseshenqiSmad ProteinsTOR Serine-Threonine KinasesTransforming Growth Factor betaALOX5AMPK/mTOR pathwaydiabetic nephropathyferroptosisShenqi Dihuang decoctionTGF-β/Smads pathway

Identifiers

PMID41789254
PMCPMC12957774

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.