Evidence map›Paper›PMID 41789300›Full record

ArticleACS pharmacology & translational science2025

Assessing the Potential Cardiovascular Risk of Microdosing the Psychedelic LSD in Mice.

Devin P Effinger, Serena S Schalk, Jillian L King, Janae R Wallingford, Caden K O'Connell, Joselynn R Calderon, Benjamin J Kopecky, John D McCorvy, Scott M Thompson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The working lives of neuronal 5-HTRSC chemical biology · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Devin P EffingerLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Serena S SchalkLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Jillian L KingLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Janae R WallingfordLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Caden K O'ConnellLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Joselynn R CalderonLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Benjamin J KopeckyDivision of Cardiology, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.
John D McCorvyLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.ORCID https://orcid.org/0000-0001-7555-9413
Scott M ThompsonLaboratory of Translational Psychiatry, Department of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045, United States.ORCID https://orcid.org/0000-0001-9844-9049

Funding

Investigations into 5-HT2A signaling mechanisms of psychedelic drugs for the treatment of stimulant use disorderR01DA061433 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI ADAM L. Halberstadt, John D McCorvy · 2024 to 2026
$1.5M
Advanced Small Animal Ultrasound Imaging - Vevo F2S10OD034423 · OD · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2023 to 2023
$455k
NIDA NIH HHS R01 DA061433NIH HHS S10 OD034423
6 · The paper itself

Abstract

Microdosing, the prolonged ingestion of psychedelics at subhallucinogenic doses, has gained popularity for its perceived cognitive and emotional benefits. Psychedelics have high affinity for 5-HT

Indexed as

5-HT2B receptorcardiovascularLSDmicrodosingpsychedelics

Identifiers

PMID41789300
PMCPMC12959173

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.