Evidence map›Paper›PMID 41789618›Full record

ArticleInternational journal of molecular medicine2026

Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend.

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng and 5 more

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In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Peng-Yao Lin *Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Jia-Rong Xie *Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Tian-Chen QianDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, P.R. China.
Shi-Song WangDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Si-Yi YuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Wen-Bo ShiDepartment of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Ying WangDepartment of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Lu-Ze CenDepartment of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Qing-Jing ZhuDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310027, P.R. China.
Yi-Yang ZhengDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Hui GaoDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Rong FangNingbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang 315021, P.R. China.
Zhao-Xia XiaNingbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang 315021, P.R. China.
Ai-Ming LiuDepartment of Pharmacology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Lei XuDepartment of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food additive acesulfame‑K (AK), a non‑nutritive sweetener, is widely used as a low‑calorie sugar substitute to reduce energy intake. However, its potential impact on nonalcoholic fatty liver disease (NAFLD) and the involvement of peroxisome proliferator‑activated receptor α (PPARα) remain unclear. In the present study, male wild‑type (WT) and PPARα‑null (KO) mice fed a 60% high‑fat diet were treated with AK (2 mg/ml) in drinking water for 12 weeks to evaluate the effects of chronic AK exposure on NAFLD progression and the role of PPARα. PPARα inhibition and activation strategies were further applied in

Indexed as

LiverNon-alcoholic Fatty Liver DiseasePhospholipase C betaPPAR alphaThiazinesAnimalsDiet, High-FatHumansLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionacetosulfamePhospholipase C betaPPAR alphaThiazinesacesulfame‑Knonalcoholic fatty liver diseaseperoxisome proliferator‑activated receptor αphospholipase C betasweet taste receptor

Identifiers

PMID41789618
PMCPMC12948555

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.