Evidence map›Paper›PMID 41789665›Full record

ArticleOncology reports2026

Role of iron and TfR1 in the application of high‑dose ascorbate against pancreatic cancer.

Alban Piotrowsky, Christian Leischner, Hendrik Schmieder, Katja Detert, Kathrin Schneider, Johanna Schulte, Sabrina Hammerschmidt, Luigi Marongiu, Olga Renner, Markus Burkard and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alban PiotrowskyDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Christian LeischnerDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Hendrik SchmiederDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Katja DetertDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Kathrin SchneiderBavarian Center for Cancer Research (BZKF), D‑86156 Augsburg, Germany.
Johanna SchulteDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Sabrina HammerschmidtDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Luigi MarongiuDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Olga RennerHochschule Niederrhein, University of Applied Sciences, Faculty of Food and Nutrition Sciences, D‑41065 Moenchengladbach, Germany.
Markus BurkardDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.
Sascha VenturelliDepartment of Nutritional Biochemistry, Institute of Nutritional Sciences, University of Hohenheim, D‑70599 Stuttgart, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer remains one of the deadliest tumor diseases with an urgent need for new therapy options. At the same time, the use of high‑dose vitamin C in cancer treatment has been investigated for decades. Despite promising

Indexed as

Antigens, CDAscorbic AcidChloridesFerric CompoundsIronPancreatic NeoplasmsReceptors, TransferrinApoptosisCell Line, TumorFerroptosisGene Expression Regulation, NeoplasticHumansReactive Oxygen SpeciesAntigens, CDAscorbic AcidCD71 antigenChloridesferric chlorideFerric CompoundsIronReactive Oxygen SpeciesReceptors, Transferrinascorbateironpancreatic cancerpancreatic ductal adenocarcinomaROSTfR1vitamin C

Identifiers

PMID41789665
PMCPMC12954845

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.