ArticleOncology reports2026
Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation.
Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hepatocellular carcinoma (HCC) is an aggressive liver malignancy, the molecular mechanisms underlying the progression of which are not fully understood. As a component of the chaperonin‑containing tailless complex polypeptide 1 (TCP1) ring complex, chaperonin‑containing TCP1 subunit 2 (CCT2) participates in the development of numerous types of liver disease. However, the potential role of CCT2 in regulating HCC malignant behaviors remains unclear. In the present study, bioinformatics analysis of patients with HCC from public datasets (The Cancer Genome Atlas‑Liver HCC, International Cancer Genome Consortium‑Liver Cancer‑Riken‑Japan and OEP00000321) demonstrated that CCT2 expression was upregulated in HCC tissue. High expression of CCT2 was also associated with an unfavorable overall survival prognosis. CCT2 knockdown was shown to inhibit the proliferation, migration, invasion and stemness and promote the apoptosis of HCC cells
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