Evidence map›Paper›PMID 41789672›Full record

ArticleOncology reports2026

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest.

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun

Abstract read
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In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minji BaeDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Min Kyeong LeeDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Mi Gyeong JeongDepartment of Otolaryngology‑Head and Neck Surgery, Kyung Hee University School of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Yeonseo LeeDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Harim JooDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Young Chan LeeDepartment of Otolaryngology‑Head and Neck Surgery, Kyung Hee University School of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Jung Woo LeeDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea.
Su Il KimDepartment of Otolaryngology‑Head and Neck Surgery, Kyung Hee University School of Medicine, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.
Seong-Gyu KoDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Young-Gyu EunDepartment of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide. Cisplatin, a widely used chemotherapeutic agent, exerts its anticancer effect by inducing DNA damage, and inhibiting transcription and replication. However, its repeated administration can lead to severe side effects and the development of drug resistance, thereby limiting its clinical efficacy. Thus, novel combination strategies are urgently needed to enhance the anticancer effects of cisplatin. The present study aimed to investigate the potential of Platycodin D (PD), a natural saponin extracted from

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsAutophagyCisplatinHead and Neck NeoplasmsSaponinsSquamous Cell Carcinoma of Head and NeckTriterpenesApoptosisCell Line, TumorCell ProliferationCell SurvivalDrug Resistance, NeoplasmDrug SynergismGene Expression Regulation, NeoplasticHumansPlatycodonCisplatinplatycodin DReactive Oxygen SpeciesSaponinsTriterpenesautophagycisplatinhead and neck squamous cell carcinomaPlatycodin Dreactive oxygen species

Identifiers

PMID41789672
PMCPMC12981022

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.