ArticleThe Journal of clinical endocrinology and metabolism2026
Partial pressure of oxygen-guided adrenal venous sampling in primary aldosteronism.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Partial pressure of oxygen-guided adrenal venous sampling in primary aldosteronism.The Journal of clinical endocrinology and metabolism · 2026Article
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Abstract
contextAdrenal venous sampling (AVS) plays a pivotal role in treatment optimization for primary aldosteronism (PA) to minimize cardiovascular risks. However, technical difficulties often hinder accurate cannulation to the adrenal veins (AVs).
objectiveThis study aimed to explore the distribution of partial pressure of oxygen (pO2) in the AV and neighboring veins, inspired by our awareness of the lighter red color of adrenal venous blood than the others.
methodsWe enrolled 179 PA patients who underwent AVS from 2021 to 2024. During AVS, we collected residual blood samples from bilateral AV, hepatic (HV), inferior phrenic, and external iliac veins for blood gas analysis. Statistical analysis was conducted to evaluate pO2 distributions and its associations with clinical parameters.
resultsAmong 179 patients examined, 168 received oxygen supplementation during AVS and in those cases, the pO2 levels were significantly higher in the bilateral AVs than in the HV and inferior phrenic veins at baseline, whereas the levels of partial pressure of carbon dioxide were lower. Following cosyntropin stimulation, the pO2 levels in the AVs decreased but distribution patterns across the examined veins remained similar. The pO2 evaluation provided highly accurate identification of AVs both before and after cosyntropin stimulation.
conclusionThis is the first study to examine the pO2 dynamics in the human AV and non-AVs, demonstrating its potential to improve AVS cannulation success rates. Our findings also presented the oxygen consumption in the adrenal glands for steroidogenesis. The pO2 measurement is a faster, easier and less-expensive tool enhancing AVS techniques.
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