Evidence map›Paper›PMID 41790017›Full record

ArticleRadiology. Imaging cancer2026

US Molecular Imaging of Glypican-3 Expression in Hepatocellular Carcinoma Using Targeted Biosynthetic Gas Vesicles.

Xiaoxin Liang, Lingling Li, Yuanyuan Wang, Shilin Lu, Xu Han, Fei Yan, Jianhua Zhou

Abstract readComment
In one paragraph

Article in Radiology. Imaging cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xiaoxin Liang *Department of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China.ORCID 0009-0001-1520-5469
Lingling Li *Department of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China.ORCID 0000-0003-4596-8712
Yuanyuan WangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.
Shilin LuDepartment of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China.ORCID 0009-0004-8763-7182
Xu HanDepartment of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China.ORCID 0009-0000-9342-4598
Fei Yan *State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, PR China.ORCID 0000-0003-4874-9582
Jianhua Zhou *Department of Ultrasound, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, PR China.ORCID 0000-0003-2096-8126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To develop L5 peptide-modified gas vesicles (L5-GVs) for US molecular imaging (USMI) of glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). Materials and Methods This study was conducted from October 2022 to December 2024. L5-GVs were synthesized by conjugating L5 peptides to gas vesicles derived from

Indexed as

Carcinoma, HepatocellularGlypicansLiver NeoplasmsMolecular ImagingAnimalsFemaleHep G2 CellsHumansMiceMice, Inbred BALB CMice, NudeUltrasonographyGlypicansGPC3 protein, humanAnimal StudiesContrast Agents-OtherMolecular ImagingUltrasound-Contrast

Identifiers

PMID41790017
PMCPMC13036689

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.