ArticleMikrochimica acta2026
Au@Ag spiny sphere-based SERS for the ultrasensitive and rapid detection of nicotine in mainstream cigarette smoke.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The rapid, on-site quantification of nicotine in mainstream cigarette smoke is important for public health assessment yet poses a significant analytical challenge due to the complex sample matrix. Herein, we report a surface-enhanced Raman scattering (SERS) platform based on Au@Ag spiny spheres, engineered with high-density nanotips that generate intense plasmonic hot spots for sensitive nicotine detection. The platform features a pretreatment-free strategy wherein the Au@Ag colloid serves a dual role as both an in-situ extraction phase and the SERS-active substrate. This integration of sampling and detection yields a 150-fold signal enhancement and a 0.42 µg/mL limit of detection, with each analysis completed within 5 s. The method’s accuracy was validated across eight commercial cigarette brands, demonstrating excellent agreement with standard gas chromatography (RSD < 3.54%). This work thus provides a practical, field-deployable SERS approach that addresses key limitations of conventional analysis, enabling rapid quantification of public health-relevant chemical exposure.
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