Differential Intestinal Epithelial Injury Following Passive and Exertional Hyperthermia.

Sharifah Badriyah Alhadad, Louisa Si Xian Lim, Jason Kai Wei Lee, Ivan Cherh Chiet Low

Abstract read

In one paragraph

Article in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sharifah Badriyah AlhadadDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Block MD9, 2 Medical Drive Level 4, Singapore, 117593, Singapore.ORCID http://orcid.org/0000-0002-1391-7681

Louisa Si Xian LimDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Block MD9, 2 Medical Drive Level 4, Singapore, 117593, Singapore.

Jason Kai Wei LeeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Block MD9, 2 Medical Drive Level 4, Singapore, 117593, Singapore.ORCID http://orcid.org/0000-0003-4042-795X

Ivan Cherh Chiet LowDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Block MD9, 2 Medical Drive Level 4, Singapore, 117593, Singapore. phsilcc@nus.edu.sg.ORCID http://orcid.org/0000-0003-2735-395X

Funding

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore

6 · The paper itself

Abstract

backgroundPassive and exertional hyperthermia can compromise gastrointestinal (GI) integrity, contributing to systemic complications and heat stroke. Intestinal epithelial injury, a potential early event in this cascade, is likely multi-factorial and context-dependent, influenced by thermal, metabolic and mechanical stress. We compared the effects of passive hyperthermia (PaH) and exertional hyperthermia (RUN) at matched peak body core temperature (T

methodsIn this randomised, counterbalanced, repeated-measures study conducted per CONSORT guidelines, 15 male endurance athletes (age: 26 ± 3 years, VO

resultsPeak T

conclusionsIntestinal epithelial injury occurred following exertional, but not passive hyperthermia, at matched peak T

Indexed as

Core temperatureExertional heat strokeGastrointestinal injuryHeat stressIntestinal fatty acid binding protein

Identifiers

PMID41790336

DOI10.1186/s40798-026-00998-y

PMCPMC12965931

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.