Evidence map›Paper›PMID 41790549›Full record

ArticleSTAR protocols2026

Atopic march protocol involving sequential skin and lung inflammation elicited by epicutaneous Staphylococcus aureus and allergen exposure.

Sabrina N Kline, Laine E Feller, Danielle Wills, Rishi Damarla, Nathan K Archer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabrina N KlineDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Laine E FellerDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Danielle WillsDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Rishi DamarlaDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. Electronic address: narcher2@jhmi.edu.

Funding

Multivalent Toxoid Vaccine for recurrent Staphylococccus aureus diseaseR01AI111205 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI M Javad Aman · 2015 to 2026
$6.9M
Protective versus deleterious immune responses that impact vaccine efficacy against Staphylococcus aureus bloodstream infectionR01AI146177 · NIAID · INTEGRATED BIOTHERAPEUTICS, INC. · PI AMAN, M JAVAD, ARCHER, NATHAN K. · 2020 to 2024
$3.5M
IL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8M
Future Academic Scientists in DermatologyT32AR074920 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Luis Andres Garza · 2020 to 2026
$1.4M
NIAID NIH HHS R01 AI111205NIAID NIH HHS R01 AI146177NIAMS NIH HHS R01 AR073665NIAMS NIH HHS T32 AR074920
6 · The paper itself

Abstract

The prevalence of allergic diseases is rising globally, and these diseases often follow a sequential pattern of disease onset in childhood, beginning with atopic dermatitis, followed by food allergy, asthma, and allergic rhinitis. Here, we present a protocol for modeling this "atopic march" in mice. We describe the steps for inducing atopic dermatitis-like skin inflammation through Staphylococcus aureus epicutaneous exposure. We then detail procedures for eliciting lung inflammation via skin allergen sensitization and subsequent intratracheal allergen elicitation in the lungs. For complete details on the use and execution of this protocol, please refer to Kline et al.

Indexed as

AllergensDermatitis, AtopicPneumoniaSkinStaphylococcus aureusAnimalsDisease Models, AnimalFemaleLungMiceAllergensCell isolationFlow cytometryHealth sciencesImmunologyMicrobiologyModel organismsSingle cell

Identifiers

PMID41790549
PMCPMC12992948

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.