Evidence map›Paper›PMID 41790695›Full record

ArticleMedicine2026

Association between relative fat mass and rheumatoid arthritis: A cross-sectional study.

Yuanting Sun, Ruiji Wu, Yanze Lin

Abstract read
In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuanting SunFuyang TCM Hospital of Orthopedics Affiliated to Zhejiang Chinese Medical University (Hangzhou Fuyang Hospital of Orthopedics of Traditional Chinese Medicine), Hangzhou, Zhejiang, China.
Ruiji WuDepartment of Orthopaedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Yanze LinDepartment of Orthopaedics, The Third People's Hospital of Yuhang District, Hangzhou, Zhejiang, China.ORCID 0000-0002-7248-3182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity has been recognized as a significant contributor to the development of rheumatoid arthritis (RA). Relative fat mass (RFM), a newly proposed anthropometric index, offers an alternative method for estimating body fat percentage. This cross-sectional study aims to elucidate the potential association between RFM and RA risk. Data were obtained from the National Health and Nutrition Examination Survey 1999 to 2018. Weighted multivariable logistic regression was used to assess the independent association between RFM and RA, and subgroup interaction analyses were performed to evaluate potential effect modification. Restricted cubic spline (RCS) models were applied to explore potential nonlinear relationships. Receiver operating characteristic (ROC) curve analysis was conducted to compare the discriminatory ability of RFM and body mass index (BMI). This cross-sectional study demonstrates a positive association between RFM and RA. Although RFM offers some improvement over BMI as an obesity-related indicator, its clinical utility for identifying RA risk remains limited. A total of 43,499 participants were included in the analysis, among whom 2557 had RA. Weighted multivariable logistic regression revealed a significant positive association between RFM and RA (odds ratio = 1.048; 95% confidence interval: 1.036-1.060). This association remained consistent when RFM was analyzed in quartiles, with individuals in the highest quartile showing a significantly higher risk of RA compared to the lowest quartile (odds ratio = 2.487; 95% confidence interval: 1.875-3.299). Subgroup interaction analyses revealed that this association was modified by age, educational level and smoking status. RCS analysis demonstrated a linear relationship between RFM and RA. RFM showed slightly better discrimination than BMI in ROC analysis, but the overall discriminatory performance remained modest (area under the curve = 0.614 vs 0.581).

Indexed as

Adipose TissueArthritis, RheumatoidObesityAdultAgedBody Mass IndexCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMiddle AgedNutrition SurveysRisk FactorsROC Curvecross-sectional studyNHANESrelative fat massrheumatoid arthritisROC

Identifiers

PMID41790695
PMCPMC12975257

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.