ArticleCell death discovery2026
ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy.
Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
18 authors.
Funding
Abstract
Despite the promising efficacy of anti-CD19 CAR-T cells in treating B-cell lymphoma, T cell dysfunction and exhaustion remains a critical barrier to achieving durable responses. Based on the immunomodulatory effect in the clinical trial enrolled lymphoma patients, this study aims to explore the potential of the first in class highly selective ITK inhibitor soquelitinib in enhancing the persistence and antitumor functionality of CAR-T cells. We employed flow cytometric analysis to characterize T cell populations, RNA sequencing for gene expression profiling, and tumor bearing mice models to evaluate therapeutic efficacy. Our results demonstrated that the cytotoxic and anti-tumor activities of CAR-T cells were significantly increased post ITK inhibition treatment through elevation of cytotoxic and effector molecules, such as GZMB, TNF-α and IFN-γ. Meanwhile, soquelitinib promoted the expansion of CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.