Evidence map›Paper›PMID 41792152›Full record

ArticleNPJ biofilms and microbiomes2026

Trehalose ameliorates severe acute pancreatitis by modulating gut microbial metabolism.

Haibin Hao, Deren Du, Hong Lin, Lu Ke, Aikun Fu, Chongli Shi, Wei Li, Yuanzhen Li, Gaohuan Hou, Lianglan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haibin Hao *Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Deren Du *Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Hong Lin *School of Medicine, Southeast University, Nanjing, China.
Lu KeDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Aikun FuKey Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, China.
Chongli ShiDepartment of Reproductive Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wei LiDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yuanzhen LiDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Gaohuan HouSchool of Medicine, Southeast University, Nanjing, China.
Lianglan LiDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yuxiu LiuDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Shengwen ShaoThe Institute of Microbiology and Immunology, Schools of Medicine and Nursing Science, Huzhou University, Huzhou, China. shaoshw@zjhu.edu.cn.
Weiqin LiDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. liweiqindr@nju.edu.cn.
Zhihui TongDepartment of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. tongzhihui@nju.edu.cn.

Funding

National Natural Science Foundation of China 82070669National Natural Science Foundation of China 82102275National Natural Science Foundation of China 82270678Postdoctoral Fellowship Project 97157
6 · The paper itself

Abstract

This study investigates the role of trehalose in modulating gut microbiota metabolism and alleviating symptoms of severe acute pancreatitis (SAP). Here, we found that gut microbial metabolism was imbalanced in SAP. In particular, we observed increased lipid metabolism and decreased carbohydrate and amino acid metabolism, which were reversed by gut microbiota depletion. Moreover, the production of trehalose was significantly increased after gut microbiota depletion. Interestingly, trehalose treatment effectively reduced pancreatic injury and ameliorated the SAP-induced microbial metabolism imbalance by promoting carbohydrate metabolism and suppressing lipid metabolism. The effect of trehalose was depend on the gut microbiota, especially the expansion of Muribaculaceae. Mechanistically, trehalose-remodelled gut microbiota suppressed SAP-induced increases in serum TG, IL-6, IL-17A, and TNF-α levels, inhibited caspase-3-mediated apoptosis, and reduced macrophage infiltration into the pancreas. Overall, our study revealed that trehalose ameliorates SAP by modulating gut microbial metabolism homeostasis, providing new insights into the "microbial metabolism‒gut‒pancreatic axis".

Indexed as

BacteriaGastrointestinal MicrobiomePancreatitisTrehaloseAnimalsApoptosisCarbohydrate MetabolismCytokinesDisease Models, AnimalHumansLipid MetabolismMacrophagesMaleMicePancreasTumor Necrosis Factor-alphaCytokinesTrehaloseTumor Necrosis Factor-alpha

Identifiers

PMID41792152
PMCPMC13096296

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.